interleukin-17 gene expression and serum levels in acute rejected and non-rejected liver transplant patients
نویسندگان
چکیده
background: interleukin-17 (il-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. however, there is not much information about the effects of il-17 cytokine on acute liver rejection. objective: to evaluate the role of il-17 in post-liver transplant acute rejection. methods: ninety seven adult liver transplant patients who enrolled in this cross sectional study were divided into non- acute rejected (non-ar) and acute rejected (ar) patient groups. three blood samples were collected from each patient in days 1, 4 and 7 post liver transplantation. the il-17 mrna levels were evaluated using an in-house real time pcr protocol. il- 17 protein levels were also analyzed in non-ar, ar and also control groups using elisa method. results: the il-17 mrna expression level continuously increased in ar patients in all days of follow-up post liver transplantation. il-17 expression was, however, down regulated after day 4 post-transplant follow-up in non-ar patients. both il-17 mrna expression and protein levels were also significantly increased in ar patients compared with non-ar ones. conclusion: based on these findings, significant increase of il-17 mrna and protein levels in ar patients highlights the important role of il-17 in acute liver rejection.
منابع مشابه
Interleukin-17 Gene Expression and Serum Levels in Acute Rejected and non-Rejected Liver Transplant Patients
Background: Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. Objective: To evaluate the role of IL-17 in post-liver transplant acute rejection. Methods: Ninety seven adult liver transplant patients who enrolled in this cross sec...
متن کاملInterleukin-17 gene expression and serum levels in acute rejected and non-rejected liver transplant patients.
BACKGROUND Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. OBJECTIVE To evaluate the role of IL-17 in post-liver transplant acute rejection. METHODS Ninety seven adult liver transplant patients who enrolled in this cross se...
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عنوان ژورنال:
iranian journal of immunologyجلد ۱۱، شماره ۱، صفحات ۲۹-۳۹
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